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Resveratrol
+ Pterostilbene
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NAD+ Booster
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Cellular Health
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DNA Repair
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Longevity
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>99% purity
$40
*Price in AUD
Uthever™ NMN
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NAD+ Booster
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Cellular Health
-
DNA Repair
-
Longevity
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99.5% purity
$80
*Price in AUD
Berberine
+ Alpha-Lipoic Acid
​
-
AMPK Booster
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Cellular Detox
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Weight Loss
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Longevity
-
>98% purity
$45
*Price in AUD
NAD+, AN ESSENTIAL LONGEVITY MOLECULE
NAD+ is too big a molecule to be absorbed through diet, so to ensure we have sufficient levels for optimum health we can supplement its precursor molecules such as NMN or NR. Taking Resveratrol or Pterostilbene boosts the effects of NMN and NR to make more NAD+ than they do alone. Restricting calorie intake through intermittent fasting, high intensity exercise and cold exposure also boosts NAD+ levels. A combination of these is a great strategy for healthy aging.
To put it simply NAD+ does the following...
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It's fuel for the body, boosting metabolism and energy.
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It's a natural restorative that can reduce pain and promote cellular healing.
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It's neuroprotective, enhancing cognition and helping to prevent degenerative brain diseases.
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It's a regulator, helping to balance hormones and deficiencies causing depression and illness.
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It's rejuvenative, making old cells young again and extending healthspan.
As such it has also become a successful detox therapy for addiction and alcohol abuse. In addition to helping reverse bodily damage and flushing out accumulated toxins it can markably reduce the withdrawal symptoms and cravings for alcohol and opiates. Clinical IV NAD+ treatment can cost thousands however, making it more cost effective to take NAD+ precursor supplements.
Nicotinamide adenine dinucleotide (NAD+) is one of the most important molecules in the body.
Found in every living cell, it functions as a cofactor for enzymes in hundreds of cellular processes. It is also necessary for ATP energy production in mitochondria and activating sirtuins (our longevity genes) for DNA repair. Without NAD+ we would die in less than a minute, so it's essential that the body maintains a good supply of it for optimal cell maintenance. In our youth it buzzes around cells in high concentration, but as we grow older it diminishes more and more, being depleted by half around the age of 50. Without this bounty of NAD+ our cells stop functioning properly, less ATP is made, metabolism slows down and genetic mistakes are made during cell replication. Consequently we grow old, diseased and weak.
BENEFITS OF NAD+ PRECURSOR SUPPLEMENTATION
Genomic
Instability
Increased NAD+ levels lead to improved DNA repair capacity.
Low levels of NAD+ lead to increased ROS (free radical) accumulation.
Telomere
Attrition
NAD+ is associated with an increase in sirtuin activity. Increasing sirtuin activity stabilizes telomeres and reduces DNA damage.
Epigenetic
Alterations
Treatment with NAD+ precursors NMN and NR activates sirtuins, which deacetylate and activate gene transcription factors related to aging.
Loss of
Proteostasis
Increased NAD+ reduces aggregated dysfunctional proteins and triggers antioxidant defenses, prolonging lifespan and health in mice and worms.
Deregulated
Nutrient Sensing
NMN and NR can help to prevent diet-induced obesity in mice, increase energy expenditure and improve insulin sensitivity by raising NAD+ levels.
Mitochondrial
Dysfunction
Increased NAD+ in aged mice restores mitochondrial function to that of young mice in a sirtuin-dependent manner either via PGC-1a/b or AMPK.
Cellular
Senescence
Increased NAD+ decreases senescence in neuronal, mesenchymal and melanocyte stem cells by improving mitochondrial function via sirtuins.
Stem Cell
Exhaustion
Treatment with NAD+ precursors rejuvenate and prolong the lifespan of stem cell pools, leading to increased oxidative respiration and ATP levels.
Altered Intercellular
Communication
NMN and NR treatment can reverse age-related changes in expression of genes related to inflammation, partly by increasing sirtuin activity.
Compromised
Autophagy
Increased NAD+ synthesis, caused by AMPK activation through sirtuin and mTOR activation, induces autophagy in senescent cells.
How boosting NAD+ has been shown to address these hallmarks
References:
THE HALLMARKS OF AGING
There are currently considered to be nine or ten hallmarks of aging.
By addressing these dysfunctions we can extend our healthspan and lifespan.
ABOUT US
Vital Botanica is an Australian supplement store dedicated to providing the highest quality health products for promoting increased longevity and healthspan. What started out as a research hobby has become our passion and we're delighted to share it with you. We’re proud to have helped many happy customers achieve their health goals and look forward to continuing to assist many more to come! When you shop with us you're in good hands, our customer service is always on board to help you on your journey.
